Open your powerpoint presentation on the page you want to insert the pdf within. In normal view, on the slide with the pdf file, click the pdf file s icon or image, and then on the insert tab, in the links group, click action. In the action settings box, select the mouse click tab if you want to open the pdf with a click, or the mouse over tab if you want it to open when you move the pointer over the pdf file icon. Wait for the extraction to finish and download your ppt. Vismodegib is teratogenic, embryotoxic, and fetotoxic in rats at maternal exposures lower than the human exposures at the recommended dose of 150 mgday. I generate a lot of multipage pdfs from different design packages. Open the powerpoint slide where you want to insert the pdf. In 2012 vismodegib erivedge, an oral hedgehog pathway inhibitor, was approved by the us food and drug administration for the treatment of. Erivedge vismodegib capsules, for oral use initial u.
These findings were compared with simulations from a mechanismbased pk model for validation purposes and dosage justification. Erivedge capsules can cause fetal harm when administered to a pregnant woman based on its mechanism of action. Topical delivery of vismodegib using ablative fractional laser and. This is the first drug to use the hedgehog pathway to inhibit the proliferation of tumors and is also implicated in the. Erivedge capsule is indicated for the treatment of adults with metastatic basal cell carcinoma, or with. Another option is to select insert hyperlink web page or file, to link to a pdf. Link to the pdf file there and select the pdf file, then ok. Vismodegib in patients with advanced basal cell carcinoma.
Background and objective hedgehog inhibitors such as vismodegib. Select insert object to open the insert object dialog box. To open the inserted pdf file during a slide show, attach an action to it. Sonidegib was approved recently in the us and eu to treat locally advanced basal cell carcinomas labccs ineligible for curative surgery or. Insert pdf file content into a powerpoint presentation.
Advise pregnant women of the potential risks to a fetus. Open your powerpoint presentation and find the slide on which you want to insert a pdf file. Choose select from file and then browse the file you want to insert into your presentation. Both vismodegib and sonidegib bind smo and inhibit the hh pathway. Costefffectivenes of sonidegib versus vismodegib for the.
Erivedge can result in embryofetal death or severe birth defects. In rats, malformations included craniofacial anomalies, open perineum, and absent or fused digits. Erivedge vismodegib capsule is a prescription medicine used to treat adults with a type of skin cancer, called basal cell carcinoma, that has spread to other parts of the body or that has come back after surgery or that your healthcare provider decides cannot be treated with surgery or radiation it is not known if erivedge is safe and effective in children. Hi, i seem to either be missing something or have come across a feature regression in powerpoint 2016 that is really hurting my workflow. In normal view, on the slide with the pdf file, click the pdf files icon or image, and then on the insert tab, in the links group, click action. Primary analysis of stevie, an international, openlabel trial. Open the folder that contains the pdf file you want, choose the pdf file, then select ok. I would like to have the first page of the document visible if possible, and be able to open the entire document in a new window with a double click or right click. Verify pregnancy status prior to initiation of erivedge. Smallpdf will upload and start to work on the file right away.
Advise females of the need for contraception and advise males of the potential risk of erivedge exposure through semen. Download figure open in new tab download powerpoint. Vismodegib for giant, locally advanced, basal cell carcinoma and its. Erivedge capsule was administered as monotherapy at doses 150 mg orally daily in four openlabel, uncontrolled, doseranging or fixed single dose clinical trials enrolling a total of 8 patients with advanced basal cell carcinoma bcc. Pharmacokinetic dosescheduling study of hedgehog pathway. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Hedgehog pathway inhibition in advanced basal cell carcinoma. Vismodegib erivedge for advanced basal cell carcinoma ncbi. Insert pdf file content into a powerpoint presentation powerpoint. You can open the hyperlink during the presentation to display the pdf file. Erivedge exposure through semen and to use condoms with a pregnant partner or a female partner of reproductive potential. See full prescribing information for complete boxed warning.